The latest generation of weight-loss injections, which have gained global attention in recent years, are now showing promising real-world results in Indian patients. A new study conducted at Max Super Speciality Hospital, Saket, has found that over 40 per cent of patients lost at least 10 per cent of their body weight, a benchmark associated with meaningful health benefits.

Real-World Study Shows Promising Results

The research, led by endocrinologist Dr Ambrish Mithal and published in the Indian Journal of Endocrinology and Metabolism, tracked 150 overweight and obese adults undergoing treatment in routine clinical settings. Unlike controlled trials, the study reflects everyday conditions where patients may miss doses or have varying lifestyles.

On average, participants lost around 8 per cent of their body weight over six months, translating to roughly 6 to 10 kilograms for many. Nearly three-fourths of the patients achieved at least 5 per cent weight loss, considered the minimum threshold for improvements in blood sugar levels and cardiovascular risk.

Doctors noted that these results are based on short-term follow-up, and greater weight reduction is expected over longer durations. “This is not the final weight loss. With longer follow-up, especially at one year, the reduction is likely to be significantly greater,” Dr Mithal said.

Diabetes And Drug Type Influence Outcomes

The study found notable differences in outcomes depending on patient profiles. Individuals without diabetes responded significantly better, losing nearly twice as much weight as those with diabetes. Experts suggest that insulin resistance and underlying metabolic factors may limit weight loss in diabetic patients.

The type of medication also played a crucial role. Patients using tirzepatide, a newer dual-action injection, experienced faster and more substantial weight loss compared to those on semaglutide. Many reached the 10 per cent weight-loss mark within nine to ten months, although doctors emphasised that results build gradually over time rather than instantly.

Younger patients and those trying these medications for the first time also showed quicker progress, while individuals with prior exposure to similar treatments tended to lose weight at a slower pace.

Not A Magic Fix, But A Strong Support Tool

While the findings are encouraging, experts caution against viewing these injections as a quick fix. Side effects such as nausea, bloating and constipation were commonly reported, particularly in the early stages of treatment, though they were generally manageable and did not lead to discontinuation.

Importantly, the study highlights that these medications work best when combined with lifestyle changes, including diet and exercise. Even in less controlled, real-life conditions, the treatments demonstrated consistent effectiveness, strengthening confidence among doctors in their practical use.

With obesity and diabetes on the rise in India, the study signals a shift in weight management strategies, moving beyond lifestyle interventions alone to include medical therapies that can deliver measurable and sustained results.

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